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Article Navigation. Determination of minimum inhibitory concentrations Jennifer M. Andrews Jennifer M. Oxford Academic.
Google Scholar. PDF Split View Views. Cite Cite Jennifer M. Select Format Select format. The ciliary ganglion is an intraorbital neural structure approximately 3 mm in size, situated near the orbital apex, posterolateral to the globe in loose areolar tissue between the optic nerve and lateral rectus muscle.
The mean distance between the ganglion and the optic nerve was 2. Six to 10 short ciliary nerves arise from the ganglion and run forward in a curving manner with the ciliary arteries above and below the optic nerve.
In order to investigate other biologic features, we compared patients in our database who were enrolled on clinical protocols at M. MDS is distinguished from AML by a significant increase in apoptosis, 3 , 4 as assessed by caspase 3 activity measured using a tetrapeptide Ac-DEVD-pNA Calbiochem, San Diego, CA.
By contrast, there was no significant difference in caspase 3 activity between other MDS and RAEB-T Figure 1.
Of note, there was no overlap between AML and RAEB-T or other MDS in caspase 3 activity, whereas there was complete overlap between RAEB-T and other MDS.
Upon examining other clinical characteristics as shown in Tables 1 and 2 , clearly there is significant difference between AML and RAEB-T in the presence of antecedent hematologic diseases AHD , platelet count, bone marrow cellularity, and the incidence of poor-prognosis cytogenetics Table 1.
In addition, RAEB-T disease was significantly more likely to be therapy-related than AML. By contrast, comparison of RAEB-T with MDS shows no difference between the 2 groups in any of the clinical parameters, except for AHD and bone marrow cellularity.
In fact, as shown in Figure 3 , bone marrow cellularity in RAEB-T is lower than that in other MDS and AML.
The data presented here suggest that biologically RAEB-T is more likely to be an advanced stage of MDS and that it appears different from AML.
Of course, there are other biologic characteristics that we have not examined. Nevertheless, we believe our data suggest that there is sufficient biologic distinction between AML and RAEB-T to warrant retaining the latter as a separate entity.
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Close References. Article Navigation. Differences between refractory anemia with excess blasts in transformation and acute myeloid leukemia Maher Albitar , Maher Albitar.
Anderson Cancer Center Houston, TX. This Site. Google Scholar.